Eli Manning is down a key target heading into the Giants' Thursday night showdown with the Philadelphia Eagles.

New York will be without starting tight end Evan Engram and backup Rhett Ellison tonight. We knew Engram would probably be out, but Ellison, his backup, missing the matchup is a pretty tough pill to swallow.

Engram has not played since Week 3 due to a lingering knee injury. He seemed to be on track to continue his dominance at the position, but his injury timetable is unclear. Ellison is dealing with a foot injury and sat out of practice this week. 

The Giants' offense has been struggling this season. ​The team seems to be turning against a faltering Eli Manning who has only thrown for six touchdowns on the year. The offensive line is one of the worst in the league, the running game is non-existent, and Odell Beckham Jr. is continuing to be a locker room cancer. 

The absence of Ellison and Engram will leave the team with Scott Simonson and Garrett Dickerson -- two tight ends that have gone unproven in the league.

Luckily, the Eagles' passing defense leaves a bit to be desired, but their elite front will give Manning a nightmare situation up front. The 1-4 Giants have to establish some type of unity before the season is unsalvageable.